Chemoselective Synthesis of Dialkyl 2-(tert-Butylamino) -6-methyl-5-trifluoroacetyl-4H-pyran-3,4-dicarboxylates.
✍ Scribed by S. Asghari; M. Zaty; S. Safiri
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 20 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
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## Abstract An efficient synthesis of 3‐bromoacetyl‐4‐hydroxy‐6‐methyl‐2__H__‐pyran‐2‐one by bromination of dehydroacetic acid in glacial acetic acid is described. Novel 4‐hydroxy‐6‐methyl‐3‐(2‐substituted‐thiazol‐4‐yl)‐2__H__‐pyran‐2‐ones have been prepared from the reaction of 3‐bromoacetyl‐4‐hyd