The synthesis of some dialkyl 4-(3-substituted amino)phenyl-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylates
✍ Scribed by Igor Simonič; Branko Stanovnik
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1997
- Tongue
- English
- Weight
- 389 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0022-152X
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📜 SIMILAR VOLUMES
## Abstract The Hantzsch condensation of the heteroarylcarboxaldehydes 3a‐c with alkyl acetoacetates 4a‐c and alkyl 3‐aminocrotonates 5a‐b afforded the respective dialkyl 1,4‐dihydro‐2,6‐dimethyl‐4‐(heteroaryl)‐pyridine‐3,5‐dicarboxylates 6a‐f possessing a C‐4 4‐quinolinyl, 8‐quinolinyl or 1‐oxido‐
## Abstract The Hantzsch condensation of 5‐formyluracil (**1**) with methyl, isopropyl or isobutyl acetoacetate **(2a‐c)** in the presence of ammonium hydroxide afforded the respective dialkyl 1,4‐dihydro‐2,6‐dimethyl‐4‐(2,4‐dloxo‐1,2,3,4,‐tetrahydropyrimidin‐5‐yl)pyridine‐3,5‐dicarboxylate **(3a‐c