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Chemoselective Protection of Thiols versus Alcohols and Phenols. The Tosvinyl Group.

✍ Scribed by Odon Arjona; Rocio Medel; Jenny Rojas; Anna M. Costa; Jaume Vilarrasa


Publisher
John Wiley and Sons
Year
2003
Weight
142 KB
Volume
34
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

For Abstract see ChemInform Abstract in Full Text.


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The conjugate addition of aliphatic and aromatic thiols to ethynyl p-tolyl sulphone (tosylacetylene) has been managed to afford Tosvinyl derivatives chemoselectively (in the presence of oxygen nucleophiles) and stereoselectively (isomers Z) in practically quantitative yields. The conditions of choic

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