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Chemoselective inhibition of the hydrogenolysis of the MPM protective group for phenolic hydroxy functions using a PdC-pyridine catalyst

✍ Scribed by Hironao Sajiki; Hiroko Kuno; Kosaku Hirota

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 186 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(96)02309-x

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✦ Synopsis

A convenient method for the selective hydrogenation of phenolic benzyl ether, Cbz, benzyl ester, nitro and olefin functions distinguishing from the MPM (4-methoxybenzyl) protective group for the phenolic hydroxy groups was accomplished by the addition of pyridine to the PdlC-catalyzed reduction system.

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