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Chemoselective conversion of α-unbranched aldehydes to amides, esters, and carboxylic acids by NHC-catalysis

✍ Scribed by Kuwano, Satoru ;Harada, Shingo ;Oriez, Raphaël ;Yamada, Ken-ichi


Book ID
120434790
Publisher
Royal Society of Chemistry
Year
2012
Tongue
English
Weight
668 KB
Volume
48
Category
Article
ISSN
1359-7345

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Lewis base-catalyzed transformation of α
✍ Hirotoshi Kawabata; Masahiko Hayashi 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 62 KB

The reactions of a,b-unsaturated aldehydes such as (E)-cinnamaldehyde and 2-or 4-methoxycinnamaldehyde with trimethylsilyl cyanide in the presence of a catalytic amount of a Lewis base such as TTMPP and DBU afforded the corresponding saturated carboxylic acids after hydrolysis.