Chemoselective acylation for the synthesis of model compounds of polynucleotide analogs
โ Scribed by C. G. Overberger; Chengxun Lu
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1986
- Tongue
- English
- Weight
- 290 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0887-6258
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
NucleophiLic acylation of 3,44ihydroisoquinoliniinolinium salts 3 with lithiated enol ethers 6, 7, and 8 or vinyl sulfides 14 leads to the adducts 4 9 , and 16, mpctively, in mostly excellent yields. Hydrolysis of 4 alTords 94-97% of the ketones 5, which are transformed by treatment with conc. hydro
Aromatic aldehydes are smoothly converted into the corresponding acylals in good yields in the presence of 0.10 mol% Bi(OTf) 3 โขxH 2 O. Ketones are not affected under the reaction conditions. The highly catalytic nature of bismuth triflate and the fact that it is relatively non-toxic, easy to handle