An efficient method for the chemoselective synthesis of acylals from aromatic aldehydes using bismuth triflate

✍ Scribed by Marc D Carrigan; Kyle J Eash; Matthew C Oswald; Ram S Mohan

• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 218 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)01756-7

✦ Synopsis

Aromatic aldehydes are smoothly converted into the corresponding acylals in good yields in the presence of 0.10 mol% Bi(OTf) 3 •xH 2 O. Ketones are not affected under the reaction conditions. The highly catalytic nature of bismuth triflate and the fact that it is relatively non-toxic, easy to handle and insensitive to small amounts of air and moisture makes this procedure especially attractive for large-scale synthesis.