## Abstract ## BACKGROUND Hepatocellular carcinoma (HCC) is the third most common cause of cancer mortality worldwide. Survival is poor for patients with advancedβstage HCC, and small trials of tamoxifen for patients with this disease have shown conflicting results. The authors conducted a systema
β¦ LIBER β¦
Chemoprevention of hepatocellular carcinoma: Use of tamoxifen in an animal model of hepatocarcinogenesis
β Scribed by Adrian M. Di Bisceglie; Patricia Osmack; Elizabeth M. Brunt
- Book ID
- 113772602
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 142 KB
- Volume
- 145
- Category
- Article
- ISSN
- 1532-6543
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Hepatocellular carcinoma (HCC) remains a common cancer worldwide that lacks effective chemoprevention or treatment. Chronic liver disease often leads to impaired hepatic S-adenosylmethionine (SAMe) biosynthesis, and mice with SAMe deficiency develop HCC spontaneously. SAMe is antiapoptotic in normal