S-adenosylmethionine in the chemoprevent
S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model
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Shelly C. Lu; Komal Ramani; Xiaopeng Ou; Mark Lin; Victor Yu; Kwangsuk Ko; Ryan
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Article
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2009
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John Wiley and Sons
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English
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Hepatocellular carcinoma (HCC) remains a common cancer worldwide that lacks effective chemoprevention or treatment. Chronic liver disease often leads to impaired hepatic S-adenosylmethionine (SAMe) biosynthesis, and mice with SAMe deficiency develop HCC spontaneously. SAMe is antiapoptotic in normal