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Chemoprevention of carcinogen-DNA binding: the relative role of different oxygenated substituents on 4-methylcoumarins in the inhibition of aflatoxin B1-DNA binding in vitro

✍ Scribed by Hanumantharao G. Raj; Sangita Gupta; Gopa Biswas; Suddham Singh; Amarjit Singh; Amitabh Jha; Kirpal S. Bisht; Sanjay K. Sharma; Subhash C. Jain; Virinder S. Parmar


Book ID
108480544
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
365 KB
Volume
4
Category
Article
ISSN
0968-0896

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Indole-3-carbinol (I3C), a naturally occurring inhibitor of experimental carcinogenesis, was evaluated for its possible inhibitory effect on DNA-adduct formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a dietary mutagen, in female F344 rats. PhIP is a mammary carcinogen in female