In vitromicrosome-mediated aflatoxin B1-DNA binding and its inhibition by cytosol of various organs of the hamster and quail

Inactivation of the DNA repair gene O6-m

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B1-DNA adducts and p53 mutation in hepatocellular carcinoma

✍ Yu-Jing Zhang; Yu Chen; Habibul Ahsan; Ruth M. Lunn; Po-Huang Lee; Chien-Jen Che 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 237 KB 👁 1 views

## Abstract O^6^‐methylguanine‐DNA methyltransferase (MGMT) is a repair protein that specifically removes promutagenic alkyl groups from the O^6^ position of guanine in DNA. __MGMT__ is transcriptionally silenced by promoter hypermethylation in several human cancers. Methylation‐specific PCR (MSP)