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Chemometric approach to a QSAR study of peptides behaving as NK-2 receptor antagonists

✍ Scribed by Sergio Clementi; Gabriele Cruciani; Daniela Riganelli; Paolo Rovero; Vittorio Pestellini; Carlo Alberto Maggi; Massimo Baroni

Book ID: 103931851
Publisher: Elsevier Science
Year: 1990
Weight: 578 KB
Volume: 3
Category: Article
ISSN: 0898-5529
DOI: 10.1016/0898-5529(90)90065-g

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✦ Synopsis

This paper shows the advantages of using chemometric strategies in QSAR of NKA analogues containing D-Tryptophan and behaving as highly selective NK-2 receptor antagonists: a) detecting the sequence with optimal antagonist activity, and b) having a strategy for selecting a few most informative sequences. The data set is included on disk as RVD.DAT.

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