𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Chemokine receptor CXCR4 expression is correlated with VEGF expression and poor survival in soft-tissue sarcoma

✍ Scribed by Yoshinao Oda; Naomi Tateishi; Hiroshi Matono; Suguru Matsuura; Hidetaka Yamamaoto; Sadafumi Tamiya; Ryohei Yokoyama; Shuichi Matsuda; Yukihide Iwamoto; Masazumi Tsuneyoshi

Publisher
John Wiley and Sons
Year
2009
Tongue
French
Weight
129 KB
Volume
124
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The expression of chemokine receptor CXCR4 has been associated with poor prognosis and VEGF expression in several kinds of human malignancy. We measured CXCR4 expression levels in soft‐tissue sarcoma and compared them with VEGF expression or microvessel density (MVD). We used real‐time quantitative PCR to examine the CXCR4 and VEGF expression levels in a total 176 tumors, including 24 intermediate tumors, 24 malignant round‐cell tumors (MRCTs) and 128 malignant non‐round‐cell tumors (MNRCTs). We also assessed their immunohistochemical expression of CXCR4 and VEGF, MVD and proliferative activities, as measured by the MIB‐1‐labeling index (LI). Furthermore, we evaluated their significance with respect to patient survival rates in MNRCTs, using the Cox regression model. Within the different types of tumor tissue, the expression levels of CXCR4 (p < 0.0001) and VEGF (p < 0.0001) in MNRCTs were significantly higher than those in intermediate tumors or MRCTs. Immunohistochemical expression levels of CXCR4 and VEGF were significantly correlated with their mRNA expression levels (p < 0.0001). Significant positive correlation was found between CXCR4 and VEGF expression in 112 primary MNRCTs (r = 0.434, p < 0.0001). Moreover, both univariate (p < 0.0001) and Cox multivariate analysis (p = 0.0001) revealed that overexpression of CXCR4 was an independent adverse prognostic factor, in addition to high stage according to the American Joint Committee on Cancer and a high MIB‐1‐LI. Determination of the CXCR4 expression level as a novel marker can provide useful prognostic information for patients and it could be a candidate for molecular targeting therapy in MNRCTs of soft‐tissue sarcomas. © 2008 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Reduced expression of hMSH2 protein is c
Reduced expression of hMSH2 protein is correlated to poor survival for soft tissue sarcoma patients
✍ Helge W. Taubert; Frank Bartel; Matthias Kappler; Katja Schuster; Axel Meye; Chr 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 114 KB

## Abstract ## BACKGROUND Deregulation of DNA mismatch repair is a common mechanism for the development of hereditary nonpolyposis colon carcinoma and related familiar cancers, but it also plays a role in the tumorigenesis of sporadic cancers. Although the protein expression of the two main compon

Expression of microRNA 210 associates wi
Expression of microRNA 210 associates with poor survival and age of tumor onset of soft-tissue sarcoma patients
✍ T. Greither; P. Würl; L. Grochola; G. Bond; M. Bache; M. Kappler; C. Lautenschlä 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 321 KB

## Abstract Expression of microRNAs can affect age of tumor onset and prognosis of cancer patients. However, nothing is known about the effects of microRNAs on altered age of cancer onset and disease‐specific survival of soft‐tissue sarcoma (STS) patients. The levels of __miR‐210__, also known as h

Death receptor expression is associated
Death receptor expression is associated with poor response to chemotherapy and shorter survival in metastatic ovarian carcinoma
✍ Hiep Phuc Dong; Lilach Kleinberg; Ilvars Silins; Vivi Ann Flørenes; Claes G. Tro 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 340 KB

## Abstract ## BACKGROUND. Death receptors mediate both apoptosis and survival in cancer cells. The authors analyzed death receptor expression in metastatic ovarian carcinoma. ## METHODS. Viable tumor cells in ovarian carcinoma effusions (n = 95) were analyzed for DR4, DR5, Fas, TNFR1, and TNFR2