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CXC chemokine receptor 4 is expressed in uveal malignant melanoma and correlates with the epithelioid-mixed cell type

✍ Scribed by Stefania Scala; Caterina Ieranò; Alessandro Ottaiano; Renato Franco; Anna La Mura; Giuseppina Liguori; Massimo Mascolo; Stefania Staibano; Paolo A. Ascierto; Gerardo Botti; Gaetano De Rosa; Giuseppe Castello


Publisher
Springer-Verlag
Year
2007
Tongue
English
Weight
440 KB
Volume
56
Category
Article
ISSN
0340-7004

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The G 1 /S checkpoint of the cell cycle is regulated by p16, p53 and RB tumor suppressor genes. Loss of expression of the p16 INK4 tumor suppressor protein, the product of the CDKN2 gene, has been associated with a wide variety of human malignancies. Mutations, loss of heterozygosity and deletions o