Loss of expression of the p16INK4/CDKN2
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Lauri Talve; Ilari Sauroja; Yrjö Collan; Kari Punnonen; Tauno Ekfors
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Article
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1997
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John Wiley and Sons
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French
⚖ 155 KB
👁 2 views
The G 1 /S checkpoint of the cell cycle is regulated by p16, p53 and RB tumor suppressor genes. Loss of expression of the p16 INK4 tumor suppressor protein, the product of the CDKN2 gene, has been associated with a wide variety of human malignancies. Mutations, loss of heterozygosity and deletions o