Chemoenzymatic synthesis of the non-tricyclic antidepressants Fluoxetine, Tomoxetine and Nisoxetine
✍ Scribed by Liu, Hui-Ling; Hoff, Bård Helge; Anthonsen, Thorleif
- Book ID
- 121193565
- Publisher
- Royal Society of Chemistry
- Year
- 2000
- Weight
- 101 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1472-7781
- DOI
- 10.1039/B000846J
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📜 SIMILAR VOLUMES
Abstraet--(S)-l-Phenyl-3-buten-l-ol (1), prepared in high optical purity by enzymatic resolution of the racemate, is a convenient building block for the synthesis of (R)-fluoxetine (7a) and (R)-tomoxetine (7b). Compound 1 was converted to the title drugs by ctherification with appropriate phenols un
Serotonin and norepinephrine uptake inhibitors have proven to be indispensible for the treatment of psychiatric disorders such as anxiety and clinical depression) In addition, several members of this class have shown promise for the treatment of alcoholism, chronic pain and eating disorders such as