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Stereoselective synthesis of 2-aryloxy esters: An asymmetric approach to fluoxetine, tomoxetine and nisoxetine

✍ Scribed by Paul N Devine; Richard M Heid Jr.; David M Tschaen

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 384 KB
Volume: 53
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(97)00325-6

No coin nor oath required. For personal study only.

✦ Synopsis

Serotonin and norepinephrine uptake inhibitors have proven to be indispensible for the treatment of psychiatric disorders such as anxiety and clinical depression) In addition, several members of this class have shown promise for the treatment of alcoholism, chronic pain and eating disorders such as obesity and bulimia. 2 Fluoxetine, marketed under the trade name Prozac®, has recently surpassed the $2 billion mark in annual sales.

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