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Chemoenzymatic Synthesis of Pyrrolo[2,1- b ]quinazolinones: Lipase-Catalyzed Resolution of Vasicinone †

✍ Scribed by Kamal, Ahmed; Ramana, K. Venkata; Rao, Maddamsetty V.


Book ID
120348508
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
65 KB
Volume
66
Category
Article
ISSN
0022-3263

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An efficient and facile chemoenzymatic synthesis of duloxetine by lipase mediated resolution of 3-hydroxy-3-(2thienyl)propanenitrile has been achieved. This process also describes an enantioconvergent synthesis of duloxetine via a Mitsunobu reaction.