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Chemoenzymatic synthesis of enantiomerically pure β,γ-disubstituted γ-lactones

✍ Scribed by Fritz Theil


Book ID
108036311
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
302 KB
Volume
6
Category
Article
ISSN
0957-4166

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Enantiomerically pure β,γ-epoxyesters fr
✍ M. Larchevêque; S. Henrot 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 513 KB

The preparation of enantiomerically pure /3,~epoxyesters was achieved by chemoselective opening of &hydroxybutanoli&s with trimethylsilyliodide followed by cyclisation of the resulting iodohydrins with silver oxide. The reaction of these epoxyesters with lithio or magnesiocuprates ajorded stereochem