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Chemoenzymatic Synthesis of All Four Stereoisomers of Sphingosine from Chlorobenzene: Glycosphingolipid Precursors 1a

✍ Scribed by Nugent, Thomas C.; Hudlicky, Tomas


Book ID
126444795
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
266 KB
Volume
63
Category
Article
ISSN
0022-3263

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D-erythro-Sphingosine (1) and D-erythro -2-azidosphingosine (2) are both prepared from commercially available and cheap D-ribo -phytosphingosine (3) in a yield of 58% and 70%, respectively. A key transformation in the synthesis of D-erythro -sphingosine (1) is the palladium catalyzed regiospecific r