Chemoenzymatic Synthesis of All Four Diastereomers of 2,6-Disubstituted Piperidines through Stereoselective Monoamination of 1,5-Diketones
β Scribed by Simon, Robert C.; Zepeck, Ferdinand; Kroutil, Wolfgang
- Book ID
- 118213336
- Publisher
- John Wiley and Sons
- Year
- 2013
- Tongue
- English
- Weight
- 554 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0947-6539
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
1,4-Bis(arylsulfonyl)-1,2,3,4-tetrahydropyridines in Synthesis. Intramolecular Alkylation Reactions and Stereoselective Synthesis of anti-2,6-Disubstituted Piperidines. -Chiral tetrahydropyridines (I) undergo intramolecular aromatic substitution reactions to give benzofused bicyclic compounds (II)
Selective One-Step Synthesis of Enantiopure cis-2,5-Disubstituted Pyrrolidines or cis-3,6-Disubstituted Piperidines from the (2R,2'R)-(1,2-Ethanediyl)bis-aziridine. -Chromatographic purification of the optically active bis-aziridine (I) results in a 5-exo-tet aminocyclization to the cis-2,5-disubst