Chemoenzymatic synthesis of macrocyclic
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Wei Lu; Charles J. Sih
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Article
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1999
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Elsevier Science
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French
โ 189 KB
ยฑ)-Azemacrolides were synthesized via lipase-catslyzed intmmolccular cyclization of (~-)-hydroxy-azaesters. Further, the size of the macrocyclic lactones formed could be altered by the substituent on the nitrogen atom. This allows one to prepare a combinatorial library of azamacrolides from a small