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Chemoenzymatic polymer-supported liquid phase synthesis of glucose γ-aminobutyric ester

✍ Scribed by Carmen de Torres; Alfonso Fernández-Mayoralas

Book ID
104253138
Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
126 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

A concise, polymer-supported solution synthesis of 6-O-(g-aminobutyryl)-D-glucose has been achieved. Glucose was attached to polyethylene glycol monomethyl ether (MPEG) through an a,a%-dioxyxylyl diether linker, and, subsequently, the HO-6 hydroxyl of the glucose was regioselectively esterified with g-aminobutyric acid by a lipase-catalyzed reaction.

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