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Chemoenzymatic acylation of aminoglycoside antibiotics

✍ Scribed by Llewellyn, Nicholas M.; Spencer, Jonathan B.

Book ID
118276139
Publisher
Royal Society of Chemistry
Year
2008
Tongue
English
Weight
125 KB
Volume
32
Category
Article
ISSN
1359-7345

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## Abstract A polymeric aminoglycoside was prepared by a facile chemoenzymatic reaction. Boc‐protected aminoglycoside, amikacin, was chemoselectively esterified with divinyl sebacate at a hydroxyl group in the C6β€³ position by protease from __Bacillus subtilis__. The resulting 3,6β€²,3β€³,4‴‐tetra‐__N__

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