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Exploring the Substrate Promiscuity of Drug-Modifying Enzymes for the Chemoenzymatic Generation of N-Acylated Aminoglycosides

✍ Scribed by Keith D. Green; Wenjing Chen; Jacob L. Houghton; Micha Fridman; Sylvie Garneau-Tsodikova

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
386 KB
Volume
11
Category
Article
ISSN
1439-4227

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## Abstract __The enzyme tRNA–guanine transglycosylase (TGT, EC 2.4.2.29) catalyses a base‐exchange reaction that leads to anticodon modifications of certain tRNAs. The TGT enzymes of the eubacteria__ Zymomonas mobilis __(__Z. mobilis __TGT) and__ Escherichia coli __(__E. coli __TGT) show a differe