✍ Scribed by Qi Wu; Zhi-Chun Chen; De-Shui Lu; Xian-Fu Lin
No coin nor oath required. For personal study only.
Summary: A novel biocompatible polyelectrolyte poly(vinyl raffinose‐co‐acrylic acid) (PRCA) containing a raffinose branch was prepared via redox polymerization using Fe^2+^/K~2~S~2~O~8~/H~2~O~2~ starting from enzymatically‐synthesized monomer: 1‐O‐vinyldecanedioyl raffinose. Copolymers with different monomer feed ratios were prepared and characterized with IR, NMR, and GPC. PRCA can be alternated with polycation to form microcapsules on a crystals template by electrostatic layer‐by‐layer technique. The multilayers of PRCA/poly(methacryloyloxyethyl dimethylbenzyl ammonium chloride) (PMBA) on quartz slides and PRCA/poly(dimethyldiallyl ammonium chloride) (PDDA) on acyclovir crystals template were fabricated and characterized with UV‐Vis spectra, the microelectrophoretic measurement, and TEM. Hollow capsules can be formed after the removal of acyclovir crystals template in a buffer solution. The nano‐capsule‐carrying galactose residue is a potential targeting drug‐controlled delivery systems.
Synthesis of PRCA and TEM image of a hollow (PRCA/PDDA)~10~ capsule.
magnified imageSynthesis of PRCA and TEM image of a hollow (PRCA/PDDA)~10~ capsule.
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