Chemo-enzymatic Synthesis of 3-Deoxy-β- D -ribofuranosyl Purines and Study of Their Biological Properties
✍ Scribed by Barai, Vladimir N.; Zinchenko, Anatoli I.; Eroshevskaya, Ludmilla A.; Zhernosek, Elena V.; Balzarini, Jan; De Clercq, Erik; Mikhailopulo, Igor A.
- Book ID
- 120982423
- Publisher
- Taylor and Francis Group
- Year
- 2003
- Tongue
- English
- Weight
- 188 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0732-8311
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## Abstract A new protected 2‐deoxy‐D‐ribose derivative, 5‐__O__‐[(__tert__‐butyl)diphenylsilyl]‐2‐deoxy‐3,4‐__O__‐ isopropylidene‐__aldehydo__‐D‐ribose (5), was synthesized starting from 2‐deoxy‐D‐ribose. This compound was coupled with 2‐lithio‐4‐(4,5‐dihydro‐4,4‐dimethyloxazol‐2‐yl)pyridine givin
An unnatural base pair, 2-amino-6-(N,N-dimethylamino)purine (denoted x) and pyridin-2-one (denoted y), was designed to prove the structural requirements for base pair formation involving shape complementarity. It was expected that y might satisfy the structural requirements for pairing with x, in wh