Dedicated to
Chemo-Enzymatic Synthesis of 3-Deoxy-β-D-ribofuranosyl Purines and Study of Their Biological Properties
✍ Scribed by Vladimir N. Barai; Anatoli I. Zinchenko; Ludmilla A. Eroshevskaya; Elena V. Zhernosek; Jan Balzarini; Erik De Clercq; Igor A. Mikhailopulo
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 57 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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## Abstract A new protected 2‐deoxy‐D‐ribose derivative, 5‐__O__‐[(__tert__‐butyl)diphenylsilyl]‐2‐deoxy‐3,4‐__O__‐ isopropylidene‐__aldehydo__‐D‐ribose (5), was synthesized starting from 2‐deoxy‐D‐ribose. This compound was coupled with 2‐lithio‐4‐(4,5‐dihydro‐4,4‐dimethyloxazol‐2‐yl)pyridine givin
## Abstract The dinucleoside phosphate __Π__~d~p__Π__~d~ (**4**) was synthesized from the monomers 1‐(5′‐__O__‐monomethoxytrityl ‐ 2′ ‐ deoxy ‐ β ‐ D ‐ ribofuranosyl) ‐ 2 (1 __H__) ‐ pyridone ((MeOTr) __Π__~d~, **2**) and 1‐(5′‐__O__‐phosphoryl‐3′‐__O__‐acetyl‐2′‐deoxy‐β‐D‐ribofuranosyl)‐(1__H__)‐p