## Abstract An efficient approach to the enantioselective synthesis of a series of amino acids from either bromoacetyl bromide or glycine is described using a [2,3]‐sigmatropic rearrangement to establish the stereogenic centre at C‐2 under mild conditions. Protected allylglycine **5** is a valuable
Chemo-enzymatic syntheses of isotopically labelled L-amino acids
✍ Scribed by Nicholas M. Kelly; Bridget C. O'Neill; John Probert; Gordon Reid; Rosamund Stephen; Ting Wang; Christine L. Willis; Peter Winton
- Book ID
- 108380172
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- French
- Weight
- 251 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0040-4039
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## Abstract We have developed methods for the preparation of L‐glutamic acid, isotopically labeled with ^13^C, using commercially available purified enzymes. The procedure is sufficiently versatile that L‐glutamic acid may be labeled at any carbons or any combination of carbons using ^13^C‐labeled
## Abstract [3‐^18^O]‐L‐serine, [3‐^13^C]‐L‐serine, [3‐^18^O]‐L‐threonine, [3,4‐^13^C~2~]‐L‐threonine and [3‐^2^H]‐L‐threonine are prepared from simple commercially available, isotopically enriched starting materials like H~2~^18^O, [^13^C]‐paraformaldehyde, [^13^C~2~]‐acetaldehyde and [1‐^2^H]‐ace