𝔖 Bobbio Scriptorium
✦   LIBER   ✦

ChemMatrix® for complex peptides and combinatorial chemistry

✍ Scribed by Yésica García-Ramos; Marta Paradís-Bas; Judit Tulla-Puche; Fernando Albericio

Book ID
105359911
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
126 KB
Volume
16
Category
Article
ISSN
1075-2617

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✦ Synopsis

Abstract

CM resin is a totally PEG‐based resin, made exclusively from primary ether bonds and therefore highly chemically stable. Compared to other PEG resins, it exhibits good loading and is user friendly because of its free‐flowing form upon drying. It shows improved performance over PS resins for the preparation of hydrophobic, highly structured poly‐Arg peptides. In combination with ψPros, it allows the synthesis of small proteins such as the chemokine RANTES. Like other PEG‐based resins, CM resin swells well in biocompatible solvents such as water, thereby allowing on‐bead screening. Furthermore, the high loading of this resin permits the use of a tiny quarter of a bead as a microreactor for HPLC and MALDI‐TOF analysis, thus further extending its applications in the field of combinatorial chemistry. Copyright © 2010 European Peptide Society and John Wiley & Sons, Ltd.

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