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Chemistry, pharmacology and pharmacokinetics of N,N′,N′′ -triethylenethiophosphoramide (ThioTEPA)

✍ Scribed by M.J.van Maanen; C.J.M. Smeets; J.H. Beijnen

Book ID
117817245
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
536 KB
Volume
26
Category
Article
ISSN
0305-7372

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## Abstract The alkylating agents cyclophosphamide (CP) and __N__, __N__^′^, __N__^″^‐triethylenethiophosphoramide (thiotepa) are often co‐administered in high‐dose chemotherapy regimens. Since these regimens can be complicated by the occurrence of severe and sometimes life‐threatening toxicities,