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Inhibition of human CYP2B6 by N,N′,N″-triethylenethiophosphoramide is irreversible and mechanism-based

✍ Scribed by Tanja Richter; Matthias Schwab; Michel Eichelbaum; Ulrich M. Zanger

Book ID: 113487437
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 292 KB
Volume: 69
Category: Article
ISSN: 0006-2952
DOI: 10.1016/j.bcp.2004.10.008

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## Abstract The alkylating agents cyclophosphamide (CP) and __N__, __N__^′^, __N__^″^‐triethylenethiophosphoramide (thiotepa) are often co‐administered in high‐dose chemotherapy regimens. Since these regimens can be complicated by the occurrence of severe and sometimes life‐threatening toxicities,