Chemistry of verongida sponges VIII1-bromocompounds from the mediterranean sponges Aplysina aerophoba and Aplysina cavernicola
✍ Scribed by Patrizia Ciminiello; Ernesto Fattorusso; Martino Forino; Silvana Magno; Maurizio Pansini
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 431 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0040-4020
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Summarx: Cavernicolin-1 and Cavernicolin-2, two epimeric compounds having a y-lactam ring fused to a dibromocyclohexenone ring, have been isolated from the Mediterranean sponge Aplysina (Verongia) cavernicola. Sponges of the genus Aplysina and Ianthella' have given the tyrosine-derived2 3 compounds
## Abstract A novel, mildly antibacterial, α‐bromoenone (7‐bromocavernicolenone) has been isolated from the Mediterranean sponge __Aplysina__ (= __Verongia__) __cavernicola__. Its structure, 7‐bromo‐1,5‐dihydroxy‐2‐azabicyclo[3.3.1]non‐6‐en‐3,8‐dione (**3**), is based on X‐ray and NMR analysis and
## Abstract Butanolic extracts of the Mediterranean sponge __Aplysina__ (= __Verongia__) __cavernicola__ have given, by reverse‐phase HPLC, the antibacterial quinols (±)‐3‐bromoverongiaquinol (= (±)‐3‐bromo‐1‐hydroxy‐4‐oxo‐2,5‐cyclohexadine‐1‐acetamide; **1d)** and (±)‐3‐bromo‐5‐chloroverongiaquino