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Cavernicolin-1 and cavernicolin-2, epimeric dibromolactams from the mediterranean sponge aplysina (venongia) cavernicola

✍ Scribed by Michele D'Ambrosio; Antonio Guerriero; Pietro Traldi; Francesco Pietra

Publisher: Elsevier Science
Year: 1982
Tongue: French
Weight: 229 KB
Volume: 23
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)85613-0

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✦ Synopsis

Summarx: Cavernicolin-1 and Cavernicolin-2, two epimeric compounds having a y-lactam ring fused to a dibromocyclohexenone ring, have been isolated from the Mediterranean sponge Aplysina (Verongia) cavernicola. Sponges of the genus Aplysina and Ianthella' have given the tyrosine-derived2 3 compounds (+)-1, (+)-3,4 5a, 5b, 5 76 (A. aerophoba); 6 (A. cauliformis); 4a, 2,8 2 __-a _--6, 8,2, 12-14, 101 -c __-(A. fistularis); 9 12

4b (diastereoisomeric mixture), (+)-3, 5a, 6 (5. thiona and A. spp); 3 (5. lacunosa);

VhrU (-1-A

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