Chemistry of indoles carrying a basic function. Part 8: A new approach to the ergoline skeleton

✍ Scribed by Mária Incze; István Moldvai; Eszter Temesvári-Major; Gábor Dörnyei; Mária Kajtár-Peredy; Csaba Szántay

• Book ID: 104205330
• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 198 KB
• Volume: 59
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(03)00630-6

✦ Synopsis

Starting from N-pivaloyl-Uhle's ketone a new synthetic approach to the ergoline skeleton has been elaborated. Ring D of the tetracyclic skeleton was formed by an intramolecular Dieckmann-condensation of a diester, obtained in a Reformatsky reaction of a properly substituted derivative of N-pivaloyl Uhle's ketone followed by elimination of water.