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Chemistry of andrographolide: formation of novel di-spiropyrrolidino and di-spiropyrrolizidino-oxindole adducts via one-pot three-component [3+2] azomethine ylide cycloaddition

✍ Scribed by Abhijit Hazra; Priyankar Paira; Krishnendu B. Sahu; Subhendu Naskar; Pritam Saha; Rupankar Paira; Shyamal Mondal; Arindam Maity; Peter Luger; Manuela Weber; Nirup B. Mondal; Sukdeb Banerjee

Book ID
104097385
Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
554 KB
Volume
51
Category
Article
ISSN
0040-4039

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✦ Synopsis

A facile synthesis of novel di-spiro compounds has been achieved via 1,3-dipolar cycloaddition of azomethine ylides generated in situ from isatin derivatives and sarcosine to the conjugated double bond of andrographolide. When the amino acid was changed from sarcosine to L-proline, the product formation took a different course as determined by 2D NMR and X-ray crystallographic analysis.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Chemistry of Androg
ChemInform Abstract: Chemistry of Andrographolide (I): Formation of Novel Di-spiropyrrolidino and Di-spiropyrrolizidino-oxindole Adducts via One-Pot Three-Component [3 + 2] Azomethine Ylide Cycloaddition.
✍ Nirup B. Mondal; et al. et al. πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 25 KB πŸ‘ 1 views

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