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A Three-Component, One-Pot Synthesis of Indolizidines and Related Heterocycles via the [3+2] Cycloaddition of Nonstabilized Azomethine Ylides

โœ Scribed by Pearson, William H.; Stoy, Patrick; Mi, Yuan


Book ID
111860719
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
444 KB
Volume
69
Category
Article
ISSN
0022-3263

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Chemistry of andrographolide: formation
โœ Abhijit Hazra; Priyankar Paira; Krishnendu B. Sahu; Subhendu Naskar; Pritam Saha ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 554 KB

A facile synthesis of novel di-spiro compounds has been achieved via 1,3-dipolar cycloaddition of azomethine ylides generated in situ from isatin derivatives and sarcosine to the conjugated double bond of andrographolide. When the amino acid was changed from sarcosine to L-proline, the product forma