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Chemistry and Biology of Deoxynyboquinone, a Potent Inducer of Cancer Cell Death

โœ Scribed by Bair, Joseph S.; Palchaudhuri, Rahul; Hergenrother, Paul J.


Book ID
118057251
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
492 KB
Volume
132
Category
Article
ISSN
0002-7863

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We have reported that an inhibitor of DNA methylation, 5-azacytidine, makes cloned, antigenspecific CD4+ T cells autoreactive, and that procainamide and hydralazine mimic this effect. Those results suggested that procainamide and hydralazine may induce autoimmunity by inhibiting DNA methylation and