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Calpain-induced Bax-cleavage product is a more potent inducer of apoptotic cell death than wild-type Bax

โœ Scribed by Hiroko Toyota; Noriko Yanase; Takayuki Yoshimoto; Masami Moriyama; Tetsuo Sudo; Junichiro Mizuguchi


Book ID
117467581
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
334 KB
Volume
189
Category
Article
ISSN
0304-3835

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โœ Gui Gao; Q. Ping Dou ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 367 KB

Upon apoptosis induction, the proapoptotic protein Bax is translocated from the cytosol to mitochondria, where it promotes release of cytochrome c, a caspase-activating protein. However, the molecular mechanisms by which Bax triggers cytochrome c release are unknown. Here we report that before the i