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ChemInform Abstract: Towards a Versatile Synthesis of Kainoids. Part 2. Two Methods for Establishment of C-4 Stereochemistry.

โœ Scribed by J. E. BALDWIN; S. J. BAMFORD; A. M. FRYER; M. P. W. RUDOLPH; M. E. WOOD

Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
28
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Towards a Versatile Synthesis of Kainoids. Part 2. Two Methods for Establishment of C-4 Stereochemistry. -Starting with the compounds (I) and (IV), benzylic lactone hydrogenolysis and enamide reduction are used to generate protected C-4 aryl substituted kainoid analogues. In the last case, equal ratios of both C-4 epimers are obtained, which are deprotected to the corresponding free amino acids. -(BALDWIN,

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ChemInform Abstract: Towards a Versatile
ChemInform Abstract: Towards a Versatile Synthesis of Kainoids. Part 1. Introduction of the C-3 and C-4 Substituents.
โœ J. E. BALDWIN; S. J. BAMFORD; A. M. FRYER; M. P. W. RUDOLPH; M. E. WOOD ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 32 KB ๐Ÿ‘ 2 views

Towards a Versatile Synthesis of Kainoids. Part 1. Introduction of the C-3 and C-4 Substituents. -Starting from trans-4-hydroxy-Lproline, an enamine alkylation is used for the stereospecific introduction of the C-3 substituent of acromelic acid analogues. For the introduction of C-4 aryl substituen