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ChemInform Abstract: Towards a Versatile Synthesis of Kainoids. Part 1. Introduction of the C-3 and C-4 Substituents.

✍ Scribed by J. E. BALDWIN; S. J. BAMFORD; A. M. FRYER; M. P. W. RUDOLPH; M. E. WOOD

Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis

Towards a Versatile Synthesis of Kainoids. Part 1. Introduction of the C-3 and C-4 Substituents.

-Starting from trans-4-hydroxy-Lproline, an enamine alkylation is used for the stereospecific introduction of the C-3 substituent of acromelic acid analogues. For the introduction of C-4 aryl substituents, two approaches are explored. -(BALDWIN,

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