ChemInform Abstract: Total Synthesis of the Potent Antitumor Agent Roseophilin: A Concise Approach to the Macrotricyclic Core.

✍ Scribed by A. FUERSTNER; H. WEINTRITT

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 32 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199725237

✦ Synopsis

Total Synthesis of the Potent Antitumor Agent Roseophilin: A Concise Approach to the Macrotricyclic Core.

-The first synthesis of the intricate macrotricyclic core segment (XIV) of the title antibiotic is presented. The approach merges the potential of an established Pd-catalyzed macrocyclization reaction with a concepturally new entry into substituted ketopyrroles. -(FUERSTNER, A.