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ChemInform Abstract: Total Synthesis of the Antimicrotubule Agent (+)-Discodermolide Using Boron-Mediated Aldol Reactions of Chiral Ketones.

โœ Scribed by Ian Paterson; Gordon J. Florence; Kai Gerlach; Jeremy P. Scott


Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
31
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Remote, 1,5-anti St
โœ I. PATERSON; K. R. GIBSON; R. M. OBALLA ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 34 KB ๐Ÿ‘ 1 views

Remote, 1,5-anti Stereoinduction in the Boron-Mediated Aldol Reactions of ฮฒ-Oxygenated Methyl Ketones. -The title reaction is investigated with different kinds of aldehydes leading to the desired aldol products with a high level of substrate-based 1,5-stereocontrol. The products are suitable syntho