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ChemInform Abstract: Total Synthesis of the 5-HT3 Receptor Antagonist Palonosetron.

✍ Scribed by B. A. KOWALCZYK; C. A. DVORAK

Book ID
112040760
Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
27
Category
Article
ISSN
0931-7597

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## Abstract Syntheses of labelled versions of 5‐HT~3~ receptor antagonists, Alosetron and Lurosetron, are described. [^14^C]Alosetron was prepared by routes utilizing either Fischer indolisation of an amidohydrazine or palladium‐mediated cyclisation of an aryl enaminone as key steps. ^2^H and ^13^C