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ChemInform Abstract: Total Synthesis of Epothilone B, Epothilone D, and cis- and trans-9,10-Dehydroepothilone D.
β Scribed by James D. White; Rich G. Carter; Kurt F. Sundermann; Markus Wartmann
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 27 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0931-7597
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Total Synthesis of (-)-Epothilone A. -A key step in the synthesis of the title antitumor natural product is the highly stereoselective aldol reaction of the optically active building blocks (I) and (II). Esterification of the product (IV) with the subunit (V) leads to the stereochemically homogeneou