Total Synthesis of Cytosporone B
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He Huang; Lei Zhang; Xiaodong Zhang; Xun Ji; Xiao Ding; Xu Shen; Hualiang Jiang;
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Article
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2010
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John Wiley and Sons
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English
β 57 KB
## Abstract The total synthesis of Cytosporone B, a naturally occurring agonist for Nur77, has been accomplished. The key steps are the sequential Grignard reaction and Lemieuxβvan Rudloff oxidation followed by a deprotection of the methyl aromatic ether to phenol and subsequent FriedelβCrafts acyl