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ChemInform Abstract: Total Synthesis of (+)-Cortistatin A.

โœ Scribed by K. C. Nicolaou; Ya-Ping Sun; Xiao-Shui Peng; Damien Polet; David Y.-K. Chen


Publisher
John Wiley and Sons
Year
2008
Weight
18 KB
Volume
39
Category
Article
ISSN
0931-7597

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Total Synthesis of (-)-Epothilone A. -A key step in the synthesis of the title antitumor natural product is the highly stereoselective aldol reaction of the optically active building blocks (I) and (II). Esterification of the product (IV) with the subunit (V) leads to the stereochemically homogeneou