ChemInform Abstract: Total Synthesis of (-)-Balanol.

✍ Scribed by H. MIYABE; M. TORIEDA; T. KIGUCHI; T. NAITO

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 35 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199743261

✦ Synopsis

Total Synthesis of (-)-Balanol.

-The total synthesis of the potent protein kinase C inhibitor is accomplished via a radical cyclization approach to the hexahydroazepine ring (→ (II)), an asymmetric esterification (. fwdarw. (VI)), and a biomimetic route to the benzophenone fragment (. fwdarw. (X)).