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ChemInform Abstract: Three-Component Synthesis of 1-Substituted 4-Acetyl-3-hydroxyspiro[2,5-dihydropyrrol-5,3′-indole]-2,2′-diones.

✍ Scribed by V. L. Gein; L. F. Gein; E. D. Kuznetsova; M. A. Sheptukha; E. P. Tsypliakova; K. D. Potiemkin

Publisher: John Wiley and Sons
Year: 2009
Weight: 21 KB
Volume: 40
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200923112

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Synthesis of 5H-Pyrazino(2,3-b)indoles from Indole-2,3-dione Derivatives. -The reaction of the N-acetylisatins (I) with ethylenediamine yields the products (III). After dehydrogenation these compounds and their analogues (IV) after deacetylation are cyclized by heating to the title products (VI). N