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ChemInform Abstract: The Synthesis of a Thymine Containing E-Olefinic Peptide Nucleic Acid (OPA) Monomer.

✍ Scribed by Christopher D. Roberts; Rolf Schuetz; Christian J. Leumann

Publisher: John Wiley and Sons
Year: 2010
Weight: 24 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199934247

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Stereoselective Synthesis of a Thymine Derivative of (S)-2-Hydroxy-4-(2-aminophenyl)butanoic Acid. A Novel Building Block for the Synthesis of Aromatic Peptidic Nucleic Acid Oligomers. -The synthesis of the title thymidine (VIII) is achieved via stereoselective reduction of the keto acid (I) using