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ChemInform Abstract: The Medicinal Chemist′s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

✍ Scribed by Stephen D. Roughley; Allan M. Jordan


Publisher
John Wiley and Sons
Year
2011
Weight
18 KB
Volume
42
Category
Article
ISSN
0931-7597

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Abstract

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An Exploration of the Scope for Radical-Mediated Transannular Diels-Alder Reactions in Polycycle Synthesis. -Radical-mediated cyclization of the ynone substrates (I), (III), and (V) leads to formation of different types of polycyclic compounds. Reaction mechanisms are proposed.